Digital Pulsewave Analyzer

The DPA provides information on arterial wall stiffness and determines the
biological age of arteries in less than 3 minutes. This FDA approved,
user-friendly, non-invasive device uses a finger probe to observe the changes
in pressure, blood flow, velocity and profile throughout the whole pulse wave.

Aging and disease states associated with an increase in cardiovascular
events alter the physical characteristics of blood vessel walls and impair the
pulsatile function of arteries. Impaired pulsatile function of arteries provides
important prognostic and therapeutic information beyond that provided by
traditional blood pressure measurements.

We believe that the use of the DPA can help caregivers reduce cardiovascular
disease in their patient/client populations through early detection and
prevention, and ultimately assist to decrease the associated financial costs
placed on the health care industry.
Cardiovascular disease is the #1 killer for
both men & women in the United States with an estimated economic cost of
approximately $298 billion.

In summary the DPA provides:
Early detection of arterial wall
stiffness, Biological age of arteries
Information regarding efficacy
of treatment choices
A tool to monitor the arterial wall
response to lifestyle changes /
reduction of cardiovascular risk factors
Digital Pulse Analyzer (DPA) - Heart Rate Variability













The DPA now has an added software feature that measures Heart Rate
Variability
. Decreased HRV implies decreased ability to respond to changes
in the environment. Too much consistency in heart rate (less variability) is
often associated with dysfunction and disease. The DPA software analyzes
imperceptible changes in the heart rate waveforms, provides indices and
evaluates the current body condition and activities/balances of the autonomic
nervous system.

Low HRV has been shown in numerous longitudinal studies to be related to a
higher mortality rate in both healthy and unhealthy subjects. It thus can be
shown to be a strong predicator of all-cause mortality. The heart is not just a
simple pump, but a complex sensory organ with its own functional "heart brain"
that communicates with and influences the brain via the nervous system,
hormonal system and other pathways.

Research has shown that these influences profoundly affect brain function
and most of the body's major organs. Science now confirms that stress
significantly increases the risk of heart disease, including sudden cardiac
death. Unmanaged emotional stress is equally if not more important than
physical variables in determining health outcomes. A conservative estimate is
that 75% of visits to primary care physicians are due to stress-related
disorders.

Cardiovascular-related issues are not the only uses for the DPA.
Psychologists are increasingly recognizing the importance of HRV. A number
of studies have demonstrated that patients with anxiety, phobias and
post-traumatic stress disorder (PSTD) consistently show lower HRV, even
when not exposed to a trauma related prompt. Importantly, this relationship
existed independent of age, gender, trait anxiety, cardio-respiratory fitness,
heart rate, blood pressure and respiration rate.

What is an arterial pulse wave?

The pulse wave is a physiological phenomenon, observable and measurable
in the arterial system during blood circulation. During one heart systole a
certain blood volume is expelled. This propagates through the arteries due to
the reciprocal transformation between kinetic energy of a segment of the
expelled blood volume and the potential energy of a stretched segment of the
resilient vascular wall. We can observe the changes in pressure, blood flow,
velocity and profile throughout the whole pulse wave. It can be used for
classification of the artery elasticity. 1

Why test for arterial elasticity?

"Aging and disease states associated with an increase in cardiovascular
events alter the physical characteristics of blood vessel walls and impair the
pulsatile function of the arteries. An accumulating body of evidence indicates
that impaired pulsitile function of arteries provides important prognostic and
therapeutic information beyond that provided by traditional blood pressure
measurements." 2

"The ability to detect and monitor sub-clinical damage, representing the
cumulative and integrated influence of risk factors in impairing arterial wall
integrity, holds potential to further refine cardiovascular risk stratification and
enable early intervention to prevent or attenuate disease progression."3

"Accumulating evidence suggest that abnormalities in the pulsatile
characteristics of arteries occur early in the disease processes associated
with increased cardiovascular risk, and can be favorably modified by
therapeutic interventions."4

"
We now know that the health of the endothelium and the blood
vessels directly affects overall cardiovascular health.
Cardiovascular
disease kills 500,000 Americans every year in the form of heart attack and
stroke. About 16 million more Americans suffer pain and disabilities caused by
cardiovascular disease. Today, over 60,800,000 Americans (a quarter of the
U.S. population) have one or more conditions that put them at risk for
heart attack and stroke."5

"The economic costs of these vessel diseases are staggering. In 2001, the
economic cost of all cardiovascular disease was approximately $298 billion,
including health expenditures and lost productivity"


























Waveforms Produced By The DPA

Plethysmogram (PTG) Waveform - The shape of the pulse wave is
determined, in part, by the elasticity of the blood vessels. The DPA can
analyze the shape of the curve to get early information about a developing
arterial vascular disease. The pulse wave analysis can often detect changes
very early, and is non-invasive, very easy to use, and one of the most
economical techniques available today. The DPA uses a fingertip
probe sensor - light from the LED/Photodiode is transmitted through the tissue
at the sensor site. The Photodiode detects the changes in the amount of light
absorbed by the hemoglobin which forms the PTG.

Accelerated Plethysmogram (APG) Waveform - The second derivative of
PTG - an excellent method to evaluate the biological age of arteries.

Other Measurements With The DPA

Pulse Rate
Ejection time (Etc)
Pulse Height (PH) - Pulse amplitude
Ejection Elastic Index (EEI)-- indicator of Left Ventricle ejection and
elasticity of large
arteries
Dicrotic Dilation Index (DDI)- indicator of small artery compliance
Dicrotic Elastic Index (DEI) - peripheral vessel elasticity (arterioles to
veins)
Software program to measure Heart Rate Variability (HRV)
Software program will store all patient information

DPA Advantages

Early detection of arterial wall elasticity and determination of biological arterial
age in less than 3 minutes Software program tests Heart Rate Variability
(HRV) in 5 minutes Monitors effectiveness of therapeutic intervention
Monitors arterial wall response to lifestyles changes / reduction of
cardiovascular risk factors
Non-invasive - uses a LED/Photodiode finger probe sensor.
Device is FDA approved
Lightweight and portable (12 lbs)
User friendly
Can be used alone (thermal printer) or interfaced with computer for storage of
information
Color printout data sheet when interfaced with user's computer/printer
Affordable
Revenue generator
Business Solutions

Our technology-driven health information solutions help your organization
better connect and interact with your consumers, patients, employees and
plan members. We create new capabilities for our clients with
technology-enhanced world-class health information that exceeds healthcare
industry standards. Whether you're health professional, health plan, or
independent representative, our solutions can help you:
Lead consumers to your organization's products and services
Help to influence appropriate utilization of healthcare services.
Help to build loyal relationships with your patients/customers Integrate easily
into a program, or other application.
We can create new capabilities for your organization too.
Learn more about our cost-effective screening device.

Easy-to-read, easy-to-interpret reports are:

Relevant and trustworthy
Engaging and effective
Comprehensive, yet easy to use
Help your clients see the results and effects of compliance with therapy (i.e.
supplementation)
Allow easy evaluation of the effectiveness of various therapies
Validate and document therapeutic effects for research purposes
The software provides a variety of graphic and tabular reports with statistical
summaries.

Health Professionals

Our technology-driven health information solutions help your organization
better connect and interact with your consumers, patients, employees and
plan members. We create new capabilities for our clients with
technology-enhanced world-class health information that exceeds healthcare
industry standards.

Whether you're a health professional, health plan, or independent
representative, our solutions can help you:
Lead consumers to your organization's products and services
Help to influence appropriate utilization of healthcare services
Help to build loyal relationships with your patients/customers
Integrate easily into a program, or other application
We can create new capabilities for your organization too. Learn more about
our cost-effective screening device. DPA easy-to-read, easy-to-interpret
reports can:
Help your patients see the results and effects of compliance with therapy.
Allow easy evaluation of the effectiveness of various therapies.
Validate and document therapeutic effects for study purposes.
The software provides a variety of graphic and tabular reports with statistical
summaries.

A Powerful New Tool for Health Care Professionals

As a health care professional using the DPA® Advantage, you have a
powerful new tool and advanced technology providing you with cardiovascular
parameters specific to the health of arteries. In minutes, an
easy-to-understand report and the precise data you require is available for
identifying cardiovascular disease risk in your patients.

This non-invasive system is capable of measuring arterial compliance. The
DPA®
Advantage's sensitivity to early arterial changes builds highly detailed data for
assessment in determining whether patients have potential underlying
vascular disease, as well as developing an outline for the physician of the
potential effects of patient-specific risk factors.

DPA Advantage was developed specifically for use in mobile events, clinics
and tradeshow events and can easily and successfully become an important
tool in your current patient recruitment& retention process.

Advanced Technology Arrives In Your Practice

The DPA® device measures a pulse waveform produced by the beating heart.
Data captured by the DPA® during a patient test is analyzed and reported in
just minutes to provide a clear, concise evaluation tool for health care
professionals.

Arterial stiffness indices are particularly important in identifying individuals who
exhibit the development of vascular disease, and enables the healthcare
professional to begin appropriate treatment long before the symptoms or
clinical signs appear. The DPA has many applications including:
Hypertension
Borderline Hypertension
Hyperlipidemial
Endothelial Function

Getting started: Simple, quick and painless for physician and patient

Your practice already has everything you need to begin using the DPA®
today, and  your patients' comfort and ease during the test is assured.

To begin the test, the appropriate patient-specific data is collected through a
series of questions. As your patient rests comfortably, an arterial finger pulse
sensor is  placed on the left finger. The instrument's monitor displays the
waveform as it is sensed. Once data is collected and analyzed, you simply
print the DPA Report.

The DPA® is a portable and easy-to-use "plug and play" system that requires
no additional accessories or disposable components.


Prevention

One purpose of this screening is to prevent disease before symptoms occur.
In those instances where symptoms have developed, laboratory tests results
help confirm that a problem does exist. But a normal test result is just as
significant as an abnormal result. A normal result does not mean that a test
was unnecessary. When a result is normal, it not only helps rule out disease,
but is also establishes a baseline "normal". A person's own result is the best
baseline for monitoring any change that takes place in the future.

Almost everyone in this country knows about heart disease. They know the
importance of prevention, detection, and treatment and the huge impact it has
on people's health. But they know very little about vascular disease outside
the heart.

Early Detection is Vital

In most cases, with early detection, vascular disease can be treated
effectively. The DPA test is a simple screening test that may detect these
potential problems, all of which are non-invasive and painless. The beauty of
the screening is that it is very simple. The tests do not produce any risk or
discomfort for patients, and can be done in a matter of minutes.


We sent out a flyer to many of the people in our practice. We screened 35
people our first couple of days. Of those that we screened, we had over 30 of
those buy product and get on Autoship. Then, we did another screening with
Dr. Epps the next weekend and screened over 20 people and around 15
people bought product and got on Autoship.
- Dr. Glennis Wilhoit, Missouri


I was certified on the Digital Pulsewave Analyzer in July. I went home and
immediately went to work. The results have been awsome. I was able to get 15
people on the product before the end of the month.
- Dr. Jay Wilkins, Georgia
Note:
The DPA is an
Information Tool
Only -
Final diagnosis is
the sole
responsibility of a
licensed practitioner
Digital Pulse Analyzer (DPA) – Arterial Compliance Testing
Preventative – Non-Invasive – Easy to Use – FDA Approved – Revenue
Generator
The DPA provides information on arterial wall stiffness and determines the
biological age of arteries in less than 3 minutes. This FDA approved, user-
friendly, non-invasive device uses a finger probe to observe the changes in
pressure, blood flow, velocity and profile throughout the whole pulse wave.

Aging and disease states associated with an increase in cardiovascular
events alter the physical characteristics of blood vessel walls and impair the
pulsatile function of arteries. Impaired pulsatile function of arteries provides
important prognostic and therapeutic information beyond that provided by
traditional blood pressure measurements.


Meridian believes that the use of the DPA can help caregivers reduce
cardiovascular disease in their patient populations through early detection
and prevention, and ultimately assist to decrease the associated financial
costs placed on the health care industry. Cardiovascular disease is the #1
killer for both men & women in the United States with an estimated economic
cost of approximately $298 billion

In summary the DPA provides:
• Early detection of arterial wall stiffness
• Biological age of arteries
• Information regarding efficacy of treatment choices
• A tool to monitor the arterial wall response to lifestyle changes / reduction
of    cardiovascular risk factors

Digital Pulse Analyzer (DPA) – Heart Rate Variability
The DPA now has an added software feature that measures Heart Rate
Variability. Decreased HRV implies decreased ability to respond to changes
in the environment. Too much consistency in heart rate (less variability) is
often associated with dysfunction and disease. The DPA software analyzes
imperceptible changes in the heart rate waveforms, provides indices and
evaluates the current body condition and activities/balances of the
autonomic nervous system.
Low HRV has been shown in numerous longitudinal studies to be related to a
higher mortality rate in both healthy and unhealthy subjects. It thus can be
shown to be a strong predicator of all-cause mortality. The heart is not just a
simple pump, but a complex sensory organ with its own functional "heart
brain" that communicates with and influences the brain via the nervous
system, hormonal system and other pathways.

Research has shown that these influences profoundly affect brain function
and most of the body's major organs. Science now confirms that stress
significantly increases the risk of heart disease, including sudden cardiac
death. Unmanaged emotional stress is equally if not more important than
physical variables in determining health outcomes. A conservative estimate
is that 75% of visits to primary care physicians are due to stress-related
disorders.

Cardiovascular-related issues are not the only uses for the DPA.
Psychologists are increasingly recognizing the importance of HRV. A number
of studies have demonstrated that patients with anxiety, phobias and post-
traumatic stress disorder (PSTD) consistently show lower HRV, even when
not exposed to a trauma related prompt. Importantly, this relationship existed
independent of age, gender, trait anxiety, cardio-respiratory fitness, heart
rate, blood pressure and respiration rate.
The DPA is an Information Only Tool - Final diagnosis is the sole
responsibility of a licensed practitioner
doctor.  She does not diagnose, prescribe, or treat disease or illness.